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KMID : 0371619870030020257
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Journal of Wonkwang Medical Science
1987 Volume.3 No. 2 p.257 ~ p.262
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A Study on the Inhibition of Nucleolar Organizer Region Actinomycin D
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姜榮/Kang, Young
金丁中/韓斗錫/鄭然泰/Kim, Jeong Joong/Han, Du Seok/Chung, Yeun Tai
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Abstract
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Stainability of nucleolar organizer region with silver solution in human rnetaphase chromosome was investigated to detect the polymorphism amc g different individuals and the intensity of silver staining of nucleolar organizer region in interphase cells was investigated to analyze the preferential inhibition of the synthesis of rRNA by actinomycin D in cultures
of human peripheral lymphocytes.
The results obtained were as followings ;
1. The average number of silver positive nucleolar organizer region in human acrocentric chromosome was varying 6.5?9.2.
2. The amount of silver positive material in the interphase cells decre-
ased with according as dose and treated time of actinomycin D.
Results described indicate each individual showed remarkable variation in number of silver positive nucleolar organizer region and actinomycin. D inhibited silver positive nucleolar organizer region activity.
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KEYWORD
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